Linoleate deficiency in rats measurement of carbon recycling from linoleate and a comparison with essential fatty acid deficiency.

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Published by National Library of Canada in Ottawa .

Written in English

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Edition Notes

Thesis (M.Sc.) -- University of Toronto, 1998.

Book details

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL18811592M
ISBN 100612408272

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Linoleic acid (LA) is a polyunsaturated omega-6 fatty acid and is one of two essential fatty acids for humans, who must obtain it through their diet. It is a colorless or white oil that is virtually insoluble in water.

The word "linoleic" derives from the Greek word linon (). Oleic means "of, relating to, or derived from oil of olive" or "of or relating to oleic acid" because saturating the Beilstein Reference: Rats maintained on the diet deficient in essential fatty acids were placed on the diet at 19 days (rats weaned at an earlier age and started on the essential fatty- acid deficient diet had a high mortality rate) and showed typical signs of essential fatty-acid deficiency at weeks (Bailey et al., ; Odutuga & Prout, ) and 10 were Cited by: 1.

Int J Biochem. ;13(9) Reversal of brain essential fatty-acid deficiency in the rat by dietary linoleate, linolenate and by: The in vivo toxicity of ozonides, possible intermediates in ozone-induced toxicity, was investigated.

Methyl linoleate ozonide (MLO) ( mmol/ g body wt.), a model fatty acid ozonide, was administered to female Wistar rats either intravenously or intraperitoneally. After 24 h the rats were killed and the effects were by: 5. Holman's extensive evaluation of linoleate requirements Linoleate deficiency in rats book rats was based on diets devoid of α-linolenate and oleate [(n-9)], and it seems that a dietary source of α-linolenate and oleate may influence the severity of linoleate deficiency (Anderson and Cunnane ), which could then lead to a higher estimate of linoleate requirement than Cited by:   Docosahexanoate [(n-3)] derived from α-linolenate [(n-3)] is abundant in the brain and retina (Harman et al.Lamptey and Walker ), and we thus hypothesized a negative effect on brain function of (n-3) fatty acid deficiency in the presence of sufficient (n-6) fatty oral studies reported deficits in learning paradigms associated with dietary (n Cited by: Linoleic Acid is a polyunsaturated essential fatty acid found mostly in plant oils.

It is used in the biosynthesis of prostaglandins and cell membranes. Linoleic acid is a colorless to straw colored liquid.

A polyunsaturated fatty acid essential to human diet. Linoleic acid is a doubly unsaturated fatty acid, also known as an omega-6 fatty acid. Effect of dietary alpha-linolenate/linoleate balance on Linoleate deficiency in rats book lipid compositions and learning ability of rats.

Yamamoto N, Saitoh M, Moriuchi A, Nomura M, Okuyama H. Spontaneously hypertensive rats (SHR) and normotensive control, Wistar/Kyoto (WKY) rats through two generations were fed a semipurified diet supplemented either with safflower oil Cited by: Linoleic acid is an important building material for the eicosanoids, a large group of highly bioactive hormone-like substances including prostaglandins, leukotrienes, and thromboxanes that are involved in blood clotting, inflammation, and vasoconstriction.

What Is Linoleic Acid Deficiency in Celiac Disease. methyl linoleate >98 Section 4 - FIRST AID MEASURES SWALLOWED Immediately give a glass of water. First aid is not generally required. If in doubt, contact a Poisons Information Centre or a doctor.

EYE If this product comes in contact with eyes Wash out immediately with water. If irritation continues, seek medical Size: KB. Linoleate deficiency resulted in reduced feed efficiency (in males), high rates of transepidermal water loss, poor skin and coat condition, and fatty liver.

These manifestations of EFA deficiency. The amount of dietary linoleate required by experimental animals to prevent deficiency symptoms and for maintenance of the usual pattern of polyunsaturated acids has been determined to lie between 1 and 2 percent of total calories for rats (98) and swine (36).

Levels of linoleate and arachidonate in red blood cells of healthy individuals and patients with multiple sclerosis Article (PDF Available) in Journal of Neurology Neurosurgery &.

A pyridoxine-free diet containing 20% fat was given to weanling rats for 8 to 10 weeks until they showed signs of pyridoxine deficiency. The rats were then divided into 5 groups of which 4 had supplements of 10 µ and 50 µg pyridoxine for 1 or 6 days.

The rats given pyridoxine for 6 days were pair-fed against the deprived group. Each rat was then given by mouth 10 µc linoleate Cited by: 6. Signs of Copper Deficiency Copper deficiency develops rapidly in young rats and slowly in adult rats fed diets containing less than 1 mg Cu/kg.

The copper deficiency develops more rapidly when fructose or sucrose is fed than when starch is fed, and males show a greater sensitivity to copper deficiency than females with respect to both the. UNOLEATE DEFICIENCY IN RATS: MEASUREMENT OF CARBON RECYCLING FROM LINOLEATE AND A COMPARISON WiTH ESSENTIAL FATTY ACID DEFICIENCY Master of Science, Domenic Trotti Graduate Department of Nutritional Sciences University of Toronto ABSTRACT The purpose of this study was to measure the utilisation of [I-"CI-linoleate in Cited by: 1.

The accumulation of fatty acids in retina, brain, liver, and plasma of day-old rat pups consuming various levels of linoleic acid (LA, n-6) and constant α Cited by: linoleic acid [lin″o-le´ik] an essential fatty acid that cannot be synthesized by animal tissues and must be obtained in the diet.

linoleic acid (lin'ō-lē'ik as'id), Do not confuse this word with linolenic acid. 9,Octadecadienoic acid; a doubly unsaturated carbon fatty acid, occurring widely in plant glycerides, that is essential in.

Weanling male rats were fed hydrogenated coconut oil to induce essential fatty acid (EFA) deficiency. After 15 weeks, the rats were divided into six groups. Five groups were fed graded amounts of purified linolenate (18∶3ω3) with a constant amount of linoleate (18∶2ω6) for six weeks.

Fatty acid composition was determined in brain by: Male rats of Holtzman strain were fed on a semi-purified diet containing 5% maize oil or hydrogenated coconut oil, the latter deficient in essential fatty acids (EFA).

The diets were given for 12 weeks and the rats were either fed or starved for 24 h before they were killed. The livers were homogenized and 3 fractions were obtained: whole liver homogenate, liver microsomes Author: Kathleen Stitt, Ralph M. Johnson. Zinc (Zn) deficiency is a common aliment predicted to affect 17% of the world’s population.

Zinc is a vital micronutrient used for over enzymatic reactions and multiple biochemical and structural processes in the body. Although whole blood, plasma, and urine zinc decrease in severe zinc deficiency, accurate assessment of zinc status, especially in mild to moderate deficiency, is Cited by: 6.

A diet only deficient in linoleate causes mild skin scaling, hair loss,[7] and poor wound healing in rats.[8] However, achieving a deficiency in linoleic acid is nearly impossible consuming any normal diet and is thus not considered to be of clinical concern.

Iron metabolism in copper-deficient rats - Volume 25 Issue 1 - H. Marston, Shirley H. Allen, S. SwabyCited by: • Rats were placed on a hr water restriction 4 days prior to CTA Day • Conditioning Day (CTA Day): ¾1hr access to 2-bottles of the conditioned tastant: 44, 66, or 88µM linoleic acid mixed with 5 mM ethanol (ETOH) ¾30 min following the 1hr access all rats received i.p.

injections (20ml/kg dosage) of either mM LiCl (n=8); mM. Rats lick NaCl solutions less than water and the aversive quality increases with higher concentrations.

The NaCl concentrations used w 62,and mM. Citric acid is representative of the sour tastant quality and is perceived by rats to be aversive. Similar to NaCl, rats lick citric acid less than water and the aversive.

Rats like sweet/fatty food, which can cause obesity/other health problems if eaten in large amounts. Feeding twice daily - morning and evening. Remove uneaten food, change the amount so all is eaten, and they stay a healthy weight. Rats feed mainly at dawn/dusk, and drink mostly during the night.

Synthesis of linoleate and alpha-linolenate by chain elongation in the rats. January 1, flaxadmin Human Health and Nutrition Data 0 Comments Synthesis of linoleate and alpha-linolenate by chain elongation in the rats.

Year: Authors: S C Cunnane, M A Ryan, K S Craig, S Brookes, B Koletzko, H Demmelmair, J Singer, D J Kyle. PRO-VITAL'S® Mouse and Rat vitamins and minerals formula is complete, developed for high producing mouse and rats or to maintain optimum health including in the aid to control digestive disorders.

Provitals mouse and rat formula comes in different sizes, from the pet shop size of one animal to a big mouse and rat farm.5/5.

Diets high in linoleate (safflower oil) or high in α-linolenate (perilla oil) were fed to rats for 11 months, and the effects of the diets on plasma and tissue lipids were compared. The plasma levels of total cholesterol (Cho), phospholipids (PL) and triacylglycerol (TG) were significantly lower in the high α-linolenate group than in the high Cited by: 9.

The EFA deficiency was reversed after 21 days by daily, topical application of linoleic acid to the patient's skin. The ratio of eicosatrienoic acid (, n-9) to eicosatetraenoic acid (, n-6) decreased to normal levels in the skin and serum with clinical improvement of the EFA deficiency by: Adult rats’ sodium appetite linked to early polyunsaturated fat deficiency By Caroline Scott-Thomas Jul - Last updated on Jul at GMT.

RATS Version 2 Supplement 1. Overview This document describes improvements and new features added to rats since the Version 7 User’s Guide and Reference Manual were produced. These include features added in Versionsandand the DSGE instruction and Graph Style Sheets feature, which were included in Versionbut were added after the.

Rats were infused intraduodenally with (3H)glyceryl, (14C)oleoyl trioleate (TO) and mg L/h for 8 h, followed by mumol/h linoleate for 18 h.

Mesenteric lymph was collected and analyzed for TG content and by: 8. We recently showed that a combined deficiency of iron (ID) and n-3 fatty acids (n-3 FAD) in rats disrupts brain monoamine metabolism and produces greater memory deficits than ID or n-3 FAD alone.

Providing these double-deficient rats with either iron (Fe) or preformed docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) alone affected brain monoamine Cited by: 5. Trans fats vs linoleic acid TLDR: Trans fats may not be as bad as they are made out to be.

This paper is comparing a high linoleate diet (using lard) to a soya oil derived (Primex) diet where much of the linoleate has been industrially hydrogenated in to. The following paper was presented in at the National Institute of Health is Washington, DC.

The BOLD text is my emphasis. Keywords in understanding fats- Linoleate is omega-6, linolenate is omega-3 as is DHA and EPA and oleic is omega Linoleate, DHA, EPA and linolenate are all polyunsaturated fats.

Oleic omega-9 is monounsaturated fat. A tribute to Dr. Ralph T. Holman It is with great sadness we announce that Dr. Ralph T. Holman, AOCS Past President and renowned scientist has passed away at the age of AOCS extends condolences to Dr. Holman’s family and to his many : Amy Lo.

The Rat Fan Club. Rat Health Food. by Debbie “The Rat Lady” Ducommun. updated 5/12/ Rats have nutritional requirements that are very different from dogs or cats, and are more similar to that of humans.

But rats still need a diet specially formulated for them. "A diet only deficient in linoleate causes mild skin scaling, hair loss,[7] and poor wound healing in rats.[8] However, achieving a deficiency in linoleic acid is nearly impossible consuming any normal diet and is thus not considered to be of clinical concern." Look for skin experts and keep the research up.

IRON DEFICIENT Rat & Mouse Diet Values are given for information, it is calculated averages. They are indicative and have no contractual value. They are subject to variations related to culture conditions, storage and analytical methods.

An analysis of the batch concerned allows validating nutritional values. e Diet Identification. The effect of fat level of the diet on general nutrition. XI. The protective effect of varying levels of ethyl linoleate against multiple sublethal does of X-irradiation in the rat.

J. Nutrit. See also PubMed. Cuthbertson, W.F.J. The nutritional requirements of rats and mice, p. In: Laboratory Animals Bureau Collected. Essential fatty acids, or EFAs, are those fatty acids that a species requires that it can't make from other sources. Linoleic acid is an example of an EFA for dogs, and cats require both linoleic and arachidonic EFAs.

Fatty acids are further grouped into categories including omega-3 and omega-6, each with its own specific biochemical structure.High-fat diet-induced obesity in animal models Niloofar Hariri and Louise Thibault* School of Dietetics and Human Nutrition, McGill University, Quebec, Canada Epidemiological studies have shown a positive relationship between dietary fat intake and obesity.

Since rats and mice show a similar relationship, they are considered an appropriate modelCited by:

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